Midbrain D₃ Receptor Availability Predicts Escalation in Cocaine Self-administration.

ABSTRACT:

Background

Results from neuroimaging studies suggest that disruptions in flexible decision-making functions in substance-dependent individuals are a consequence of drug-induced neural adaptations. In addicted populations, however, the causal relationship between biobehavioral phenotypes of susceptibility and addiction consequence is difficult to dissociate. Indeed, evidence from animals suggests that poor decision making due to preexisting biological factors can independently enhance the risk for developing addiction-like behaviors. Neuroimaging studies in animals provide a unique translational approach for the identification of the neurobiological mechanisms that mediate susceptibility to addiction.

Methods

We used positron emission tomography in rats to quantify regional d

SUBMITTER: Groman SM 

PROVIDER: S-EPMC8954711 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature