Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble.

ABSTRACT: Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large (Dlg) and Lethal-2-giant larvae (Lgl) to form the Scribble polarity complex, and its functional dysregulation is associated with poor prognosis during viral infections. Viruses have been shown to interfere with Scribble by targeting Scribble PDZ domains to subvert the network of interactions that enable normal control of cell polarity via Scribble, as well as the localisation of the Scribble module within the cell. The influenza A virus NS1 protein was shown to bind to human Scribble (SCRIB) via its C-terminal PDZ binding motif (PBM). It was reported that the PBM sequence ESEV is a virule

SUBMITTER: Javorsky A 

PROVIDER: S-EPMC8954747 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature