Enhanced SARS-CoV-2-Specific CD4⁺ T Cell Activation and Multifunctionality in Late Convalescent COVID-19 Individuals.

ABSTRACT: Background: Examination of CD4+ T cell responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection offers useful information for the improvement of vaccination strategies against this virus and the protective effect of these T cells. Methods: We characterized the SARS-CoV-2-specific CD4+ T cell activation marker, multifunctional cytokine and cytotoxic marker expression in recovered coronavirus disease 2019 (COVID-19) individuals. Results: CD4+ T-cell responses in late convalescent (>6 months of diagnosis) individuals are characterized by elevated frequencies of activated as well as mono, dual- and multi-functional Th1 and Th17 CD4+ T cells in comparison to early convalescent (<1 month of diagnosis) individuals following stimulation with SAR

SUBMITTER: Pavan Kumar N 

PROVIDER: S-EPMC8954911 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature