Persistent Cutaneous Leishmania major Infection Promotes Infection-Adapted Myelopoiesis.

ABSTRACT: Hematopoietic stem/progenitor cells (HSPC) are responsible for the generation of most immune cells throughout the lifespan of the organism. Inflammation can activate bone marrow HSPCs, leading to enhanced myelopoiesis to replace cells, such as neutrophils, which are attracted to inflamed tissues. We have previously shown that HSPC activation promotes parasite persistence and expansion in experimental visceral leishmaniasis through the increased production of permissive monocytes. However, it is not clear if the presence of the parasite in the bone marrow was required for infection-adapted myelopoiesis. We therefore hypothesized that persistent forms of Leishmania major (cutaneous leishmaniasis) could also activate HSPCs and myeloid precursors in the C57Bl/6 mouse model of intradermal infec

SUBMITTER: Bandeira Ferreira FL 

PROVIDER: S-EPMC8954948 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature