A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1.

ABSTRACT: Hepatocellular carcinoma (HCC) remains the second leading cause of cancer related deaths worldwide. Understanding about the molecular biology of HCC and development of targeted therapies are still the main focuses of this type of disease. Here, by connecting the expression levels of FOX proteins with their associated clinical characteristics using TCGA LIHC dataset, we found that 27/40 FOX proteins were highly expressed in HCC tumors compared to normal liver tissues and their expression levels were tightly associated with HCC tumor stage, tumor grade and overall survival. Our experimental results also confirmed that FOXH1 indeed played an oncogenic role in HCC development by promoting cell growth and cell migration/invasion. Mechanistic dissection demonstrated that FOXH1-induced cell growt

SUBMITTER: Ouyang X 

PROVIDER: S-EPMC8954963 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature