Contribution of classical complement activation and IgM to the control of Rickettsia infection.

ABSTRACT: Pathogenic Rickettsia are obligate intracellular bacteria and the etiologic agents of many life-threatening infectious diseases. Due to the serious nature of these infections, it is imperative to both identify the responsive immune sensory pathways and understand the associated immune mechanisms that restrict Rickettsia proliferation. Previous studies have demonstrated that the mammalian complement system is both activated during Rickettsia infection and contributes to the immune response to infection. To further define this component of the mammalian anti-Rickettsia immune response, we sought to identify the mechanism(s) of complement activation during Rickettsia infection. We have employed a series of in vitro and in vivo models of infection to investigate the role of the classical compl

SUBMITTER: Dahmani M 

PROVIDER: S-EPMC8955150 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature