Impact of Nutrition on Age-Related Epigenetic RNA Modifications in Rats.

ABSTRACT: Nutrition plastically modulates the epigenetic landscape in various tissues of an organism during life via epigenetic changes. In the present study, to clarify whether this modulation involves RNA methylation, we evaluated global RNA methylation profiles and the expression of writer, reader, and eraser genes, encoding for enzymes involved in the RNA methylation. The study was carried out in the heart, liver, and kidney samples from rats of different ages in response to a low-calorie diet. We found that, although each tissue showed peculiar RNA methylation levels, a general increase in these levels was observed throughout the lifespan as well as in response to the six-month diet. Similarly, a prominent remodeling of the expression of writer, reader, and eraser genes emerged. Our data provid

SUBMITTER: D'Aquila P 

PROVIDER: S-EPMC8955587 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature