Mechanical-Stress-Related Epigenetic Regulation of <i>ZIC1</i> Transcription Factor in the Etiology of Postmenopausal Osteoporosis.

ABSTRACT: Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the neurological transcriptional factor zinc finger of the cerebellum 1 (ZIC1) is markedly increased in trabecular bone biopsies in the lumbar spine compared with the iliac crest, skeletal sites of high and low mechanical stress, respectively. Human trabecular bone transcriptome analyses revealed a strong association between ZIC1 mRNA levels and gene transcripts characteristically associated with osteoblasts, osteocytes and osteoclasts. This supposition is supported by higher ZIC1 expression in iliac bone biopsies from postmenopausal women with osteoporosis compared with age-matched control subjects, as well as strongly

SUBMITTER: Datta HK 

PROVIDER: S-EPMC8955993 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature