Estimating Renal Function Following Lung Transplantation.

ABSTRACT:

Background

Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. However, no prospective longitudinal studies directly comparing the performance of equations for estimating GFR in this patient population currently exist.

Methods

In total, 32 patients undergoing LTx met the study criteria. At pre-LTx and 1-, 3-, and 12-weeks post-LTx, GFR was determined by ⁵¹Cr-EDTA and by equations for estimating GFR based on plasma (P)-Creatinine, P-Cystatin C, or a combination of both.

Results

Measured GFR declined from 98.0 mL/min/1.73 m² at pre-LTx to 54.1 mL/min/1.73 m² at 12-weeks post-LTx. Equations based on P-Creatinine underestimated GFR decline after LT

SUBMITTER: Hornum M 

PROVIDER: S-EPMC8956010 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature