Autophagy characteristics and establishment of autophagy prognostic models in lung adenocarcinoma and lung squamous cell carcinoma.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC), which makes up the majority of lung cancers, remains one of the deadliest malignancies in the world. It has a poor prognosis due to its late detection and lack of response to chemoradiaiton. Therefore, it is urgent to find a new prognostic marker.

Methods

We evaluated biological function and immune cell infiltration in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients from TCGA and GEO databases between different clusters based on autophagy related hub genes. Autophagy scores were used to assess the degree of autophagy in each individual by using component analysis.

Results

Three different clusters were obtained. Gene set variation analysis, single-sample gene set enrichment analysis and survive

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8956171 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature