Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.

ABSTRACT: Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson's disease are in part due to modest decrease in expression of mitochondrial complex I subunits. By contrast, diminishing expression of mitochondrial complex I genes in lower organisms increases lifespan. Furthermore, metformin, a putative complex I inhibitor, increases healthspan in mice and humans. In the present study, we investigated whether loss of one allele of Ndufs2, the catalytic subunit of mitochondrial complex I, impacts healthspan and lifespan in mice. Our results indicate that Ndufs2 hemizygous mice (Ndufs2^+/-) show no overt impairment in aging-related motor functio

SUBMITTER: McElroy GS 

PROVIDER: S-EPMC8956724 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature