The role of endometrial staining for CD138 as a marker of chronic endometritis in predicting live birth.

ABSTRACT:

Purpose

Chronic endometritis (CE) is diagnosed via endometrial biopsy and staining for plasma cells. A threshold plasma cell count that identifies CE and predicts pregnancy outcomes has not been established, and the prevalence of plasma cells in the general infertile population is unknown. The purpose of this study was to determine the prevalence of plasma cells in the general infertile population and whether a threshold exists which predicts live birth.

Methods

Endometrial samples were obtained prospectively from 80 women undergoing IVF, embedded in paraffin, and stained for plasma cells using mouse mono-clonal antibody for CD138. Slides were reviewed at 20× magnification and 10 random images captured. Three reviewers graded each image for plasma cells. Participants underwe

SUBMITTER: Herlihy NS 

PROVIDER: S-EPMC8956753 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature