Comparison of day 5 blastocyst with day 6 blastocyst: Evidence from NGS-based PGT-A results.

ABSTRACT:

Purpose

Aneuploidy is one genetic factor leading to the failure of embryo implantation. This study aimed to investigate the relationship between the day of embryo blastulation and the ploidy status of embryo, to aid in selecting embryos with the most likelihood of of being euploid in a noninvasive way.

Methods

This retrospective study recruited women undergoing preimplantation genetic testing (PGT) for aneuploidy (PGT-A) with trophectoderm biopsy from January 2019 to December 2020. The ploidy status of embryos was determined by next-generation sequencing (NGS).

Results

Altogether, 2531 blastocysts from 839 PGT-A cycles were evaluated. The euploid rate of day 5 blastocysts was significantly higher than that of day 6 blastocysts, either from the same ovarian stimulation

SUBMITTER: Tong J 

PROVIDER: S-EPMC8956767 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature