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Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.

ABSTRACT: Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.

SUBMITTER: Chavideh R 

PROVIDER: S-EPMC89568 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature

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Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.

Chavideh R R   Sholly S S   Panaite D D   Tolmasky M E ME  

Antimicrobial agents and chemotherapy 19991101 11

Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme. ...[more]

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