Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control.

ABSTRACT: Frontal corticostriatal circuits (FCSC) are involved in self-regulation of cognition, emotion, and motor function. While these circuits are implicated in attention-deficit/hyperactivity disorder (ADHD), the literature establishing FCSC associations with ADHD is inconsistent. This may be due to study variability in considerations of how fMRI motion regression was handled between groups, or study specific differences in age, sex, or the striatal subregions under investigation. Given the importance of these domains in ADHD it is crucial to consider the complex interactions of age, sex, striatal subregions and FCSC in ADHD presentation and diagnosis. In this large-scale study of 362 8-12 year-old children with ADHD (n = 165) and typically developing (TD; n = 197) children, we investigate assoc

SUBMITTER: Nikolaidis A 

PROVIDER: S-EPMC8956922 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature