Loss of circadian rhythmicity in bdnf knockout zebrafish larvae.
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ABSTRACT:
SUBMITTER: D'Agostino Y
PROVIDER: S-EPMC8957028 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Loss of circadian rhythmicity in <i>bdnf</i> knockout zebrafish larvae.
D'Agostino Ylenia Y Frigato Elena E Noviello Teresa M R TMR Toni Mattia M Frabetti Flavia F Cigliano Luisa L Ceccarelli Michele M Sordino Paolo P Cerulo Luigi L Bertolucci Cristiano C D'Aniello Salvatore S
iScience 20220311 4
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in neuronal growth and differentiation, neuronal plasticity, learning, and memory. Using CRISPR/Cas9 technology, we generated a vital Bdnf null mutant line in zebrafish and carried out its molecular and behavioral characterization. Although no defects are evident on a morphological inspection, 66% of coding genes and 37% of microRNAs turned out to be differentially expressed in <i>bdnf</i> <sup><i>-/-</i></sup> compared with wild type ...[more]
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