Building in-house PBPK modelling tools for oral drug administration from literature information.

ABSTRACT: The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in the last years. These kind of models are examples of the "bottom up" modelling strategy, which progressively integrates into a mechanistic framework different information as soon as they become available along the drug development. For this reason PBPK models can be used with different aims, from the early stages of drug development up to the clinical phases. Different software tools are nowadays available. They can be categorized in "designed software" and "open software". The first ones typically include commercial platforms expressly designed to implement PBPK models, in which the model structure is pre-defined, assumptions are g

SUBMITTER: Grandoni S 

PROVIDER: S-EPMC8957249 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature