Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium.

ABSTRACT:

Background

This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS).

Methods

The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities.

Results

We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed anima

SUBMITTER: Gavrilovic L 

PROVIDER: S-EPMC8957266 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature