The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis.

ABSTRACT:

Objective

The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2.

Methods

Eligible studies were identified from databases including PubMed, the Cochrane Library, Embase, Web of Science and Scopus. Hand searches were also conducted in relevant bibliographies. We then extracted and pooled hazard ratio (HR) of overall survival (OS) and odds ratio (OR) of clinicopathological features.

Results

A total of 11 eligible studies containing 1,488 patients were included. Our results demonstrated that in non-small cell lung cancer (NSCLC), high DSG2 expression is associated with poor OS. However, in digestive system

SUBMITTER: Wang J 

PROVIDER: S-EPMC8957267 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature