Critical Pressure of Intramural Delamination in Aortic Dissection.

ABSTRACT: Computational models of aortic dissection can examine mechanisms by which this potentially lethal condition develops and propagates. We present results from phase-field finite element simulations that are motivated by a classical but seldom repeated experiment. Initial simulations agreed qualitatively and quantitatively with data, yet because of the complexity of the problem it was difficult to discern trends. Simplified analytical models were used to gain further insight. Together, simplified and phase-field models reveal power-law-based relationships between the pressure that initiates an intramural tear and key geometric and mechanical factors-insult surface area, wall stiffness, and tearing energy. The degree of axial stretch and luminal pressure similarly influence the pressure of tea

SUBMITTER: Ban E 

PROVIDER: S-EPMC8957392 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature