Examination of serum metabolome altered by cigarette smoking identifies novel metabolites mediating smoking-BMI association.

ABSTRACT:

Objective

The authors hypothesize that an untargeted metabolomics study will identify novel mechanisms underlying smoking-associated weight loss.

Methods

This study performed cross-sectional analyses among 1,252 participants in the Bogalusa Heart Study and assessed 1,202 plasma metabolites for mediation effects on smoking-BMI associations. Significant metabolites were tested for associations with smoking genetic risk scores among a subset of participants (n = 654) with available genomic data, followed by direction dependence analysis to investigate causal relationships between the metabolites and smoking and BMI. All analyses controlled for age, sex, race, education, alcohol drinking, and physical activity.

Results

Compared with never smokers, current and former smoke

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8957487 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature