Multiscale temporal integration organizes hierarchical computation in human auditory cortex.

ABSTRACT: To derive meaning from sound, the brain must integrate information across many timescales. What computations underlie multiscale integration in human auditory cortex? Evidence suggests that auditory cortex analyses sound using both generic acoustic representations (for example, spectrotemporal modulation tuning) and category-specific computations, but the timescales over which these putatively distinct computations integrate remain unclear. To answer this question, we developed a general method to estimate sensory integration windows-the time window when stimuli alter the neural response-and applied our method to intracranial recordings from neurosurgical patients. We show that human auditory cortex integrates hierarchically across diverse timescales spanning from ~50 to 400 ms. Moreover,

SUBMITTER: Norman-Haignere SV 

PROVIDER: S-EPMC8957490 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature