Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals.

ABSTRACT:

Background

The functional significance and mechanisms determining the development and individual variability of structural brain asymmetry remain unclear. Here, we systematically analyzed all relevant components of the most prominent structural asymmetry, brain torque (BT), and their relationships with potential genetic and nongenetic modifiers in a sample comprising 24,112 individuals from six cohorts.

Methods

BT features, including petalia, bending, dorsoventral shift, brain tissue distribution asymmetries, and cortical surface positional asymmetries, were directly modeled using a set of automatic three-dimensional brain shape analysis approaches. Age-, sex-, and handedness-related effects on BT were assessed. The genetic architecture and phenomic associations of BT were i

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8957509 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature