Developmental and etiological patterns of substance use from adolescence to middle age: A longitudinal twin study.

ABSTRACT:

Background

The common liability to addiction framework suggests the tendency to use substances is largely a general heritable liability, but little is known about how expression of liability varies across development. We evaluated average developmental trajectories and covariation underlying commonly used substances using a genetically informative prospective design spanning three decades.

Methods

Using a sample of 3762 twins across seven waves of assessment spanning ages 14-40, we modeled these relationships using two complementary approaches: piecewise latent growth and common factor modeling on four measures of alcohol, tobacco, and marijuana use RESULTS: Average use increased across adolescence and either stabilized (alcohol frequency) or declined (all others) in adultho

SUBMITTER: Zellers SM 

PROVIDER: S-EPMC8957537 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature