Gut microbiome and diet in populations with obesity: Role of the Na+/K+-ATPase transporter signaling in severe COVID-19.

ABSTRACT:

Objective

The triad of obesity, a high-protein diet from animal sources, and disturbed gut microbiota have been linked to poor clinical outcomes in patients with COVID-19. In this report, the effect of oxidative stress resulting from the Na⁺ /K⁺ -ATPase transporter signaling cascade is explored as a driver of this poor clinical outcome.

Methods

Protein-protein interactions with the SARS-CoV-2 proteome were identified from the interactome data for Na⁺ /K⁺ -transporting ATPase subunit α-1 (ATP1A1), epidermal growth factor receptor, and ERB-B2 receptor tyrosine kinase 2, using the curated data from the BioGRID Database of Protein Interactions. Data for the gene expression pattern of inflammatory response were from the Gene Expression

SUBMITTER: Khitan ZJ 

PROVIDER: S-EPMC8957587 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature