Patient characteristics associated with initiation of XR-naltrexone for opioid use disorder in clinical trials.

ABSTRACT:

Background

Extended-release injectable naltrexone (XR-naltrexone) is effective for treatment of patients with opioid use disorder (OUD), but initiation remains a barrier due to the challenge of tolerating opioid withdrawal prior to administration. Understanding factors associated with successful initiation of XR-naltrexone could facilitate its implementation through patient-treatment matching.

Methods

We combined data from five consecutive studies that sought to initiate patients with active opioid use onto XR-naltrexone using a rapid procedure consisting of minimal buprenorphine, non-opioid medications for treating opioid withdrawal, and ascending low doses of oral naltrexone. Associations between patient characteristics and initiating naltrexone were estimated with logisti

SUBMITTER: Shulman M 

PROVIDER: S-EPMC8957614 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature