Association of Persistent Rubella Virus With Idiopathic Skin Granulomas in Clinically Immunocompetent Adults.

ABSTRACT:

Importance

Vaccine-derived and wild-type rubella virus (RuV) has been identified within granulomas in patients with inborn errors of immunity, but has not been described in granulomas of healthy adults.

Objective

To determine the association between RuV and atypical granulomatous inflammation in immune-competent adults.

Design, setting, and participants

This case series, conducted in US academic dermatology clinics from January 2019 to January 2021, investigated the presence of RuV in skin specimens using RuV immunofluorescent staining of paraffin-embedded tissue sections, real-time reverse-transcription polymerase chain reaction, whole-genome sequencing with phylogenetic analyses, and cell culture by the US Centers for Disease Control and Prevention. Rubella immunogl

SUBMITTER: Wanat KA 

PROVIDER: S-EPMC8957700 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature