Mapping the Morphological Landscape of Oligomeric Di-block Peptide-Polymer Amphiphiles.

ABSTRACT: Peptide-polymer amphiphiles (PPAs) are tunable hybrid materials that achieve complex assembly landscapes by combining the sequence-dependent properties of peptides with the structural diversity of polymers. Despite their promise as biomimetic materials, determining how polymer and peptide properties simultaneously affect PPA self-assembly remains challenging. We herein present a systematic study of PPA structure-assembly relationships. PPAs containing oligo(ethyl acrylate) and random-coil peptides were used to determine the role of oligomer molecular weight, dispersity, peptide length, and charge density on self-assembly. We observed that PPAs predominantly formed spheres rather than anisotropic particles. Oligomer molecular weight and peptide hydrophilicity dictated morphology, while disp

SUBMITTER: Allen BP 

PROVIDER: S-EPMC8957712 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature