Association of TNFAIP3 gene polymorphism (rs5029939) with susceptibility and clinical phenotype of systemic lupus erythematosus.

ABSTRACT:

Objectives

This study aims to investigate the association of the tumor necrosis factor-alpha inducible protein 3 (TNFAIP3) (rs5029939) gene single nucleotide polymorphism (SNP) with the risk of systemic lupus erythematosus (SLE) and its clinical manifestations in a cohort of SLE patients.

Patients and methods

This study included a total of 180 participants (18 males, 72 females; mean age: 30.9±10.1 years; range 17 to 59 years) including 90 SLE patients and 90 healthy controls between March 2017 and February 2020. The TNFAIP3 rs5029939 gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in all participants.

Results

There was a significant difference in genotype distribution of the TNFAIP3 rs5029939 SNP betwe

SUBMITTER: Gaballah H 

PROVIDER: S-EPMC8957768 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature