Immunological Disorders: Regulation of Ca²⁺ Signaling in T Lymphocytes.

ABSTRACT: Engagement of T cell receptors (TCRs) with cognate antigens triggers cascades of signaling pathways in helper T cells. TCR signaling is essential for the effector function of helper T cells including proliferation, differentiation, and cytokine production. It also modulates effector T cell fate by inducing cell death, anergy (nonresponsiveness), exhaustion, and generation of regulatory T cells. One of the main axes of TCR signaling is the Ca²⁺-calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway. Stimulation of TCRs triggers depletion of intracellular Ca²⁺ store and, in turn, activates store-operated Ca²⁺ entry (SOCE) to raise the intracellular Ca²⁺ concentration. SOCE in T cells is mediated by the Ca²⁺ release-acti

SUBMITTER: Srikanth S 

PROVIDER: S-EPMC8957800 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature