Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a childhood prevalence of 5%. In about two-thirds of the cases, ADHD symptoms persist into adulthood and often cause significant functional impairment. Based on the results of family and twin studies, the estimated heritability of ADHD approximates 80%, suggests a significant genetic component in the etiological background of the disorder; however, the potential genetic effects on disease risk, symptom severity, and persistence are unclear. This article provides a brief review of the genome-wide and candidate gene association studies with a focus on the clinical aspects, summarizing findings of ADHD disease risk, ADHD core symptoms as dimensional traits, and other traits frequently associated with ADHD, w

SUBMITTER: Balogh L 

PROVIDER: S-EPMC8957927 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature