Upregulation of MTA1 in Colon Cancer Drives A CD8⁺ T Cell-Rich But Classical Macrophage-Lacking Immunosuppressive Tumor Microenvironment.

ABSTRACT:

Background

The MTA1 protein encoded by metastasis-associated protein 1 (MTA1) is a key component of the ATP-dependent nucleosome remodeling and deacetylase (NuRD) complex, which is widely upregulated in cancers. MTA1 extensively affects downstream gene expression by participating in chromatin remodeling. Although it was defined as a metastasis-associated gene in first reports and metastasis is a process prominently affected by the tumor microenvironment, whether it affects the microenvironment has not been investigated. In our study, we elucidated the regulatory effect of MTA1 on tumor-associated macrophages (TAMs) and how this regulation affects the antitumor effect of cytotoxic T lymphocytes (CTLs) in the tumor microenvironment of colorectal cancer.

Methods

We detected the

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8957956 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature