Synaptopathies in Developmental and Epileptic Encephalopathies: A Focus on Pre-synaptic Dysfunction.
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ABSTRACT:
SUBMITTER: Spoto G
PROVIDER: S-EPMC8957959 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Synaptopathies in Developmental and Epileptic Encephalopathies: A Focus on Pre-synaptic Dysfunction.
Spoto Giulia G Valentini Giulia G Saia Maria Concetta MC Butera Ambra A Amore Greta G Salpietro Vincenzo V Nicotera Antonio Gennaro AG Di Rosa Gabriella G
Frontiers in neurology 20220308
The proper connection between the pre- and post-synaptic nervous cells depends on any element constituting the synapse: the pre- and post-synaptic membranes, the synaptic cleft, and the surrounding glial cells and extracellular matrix. An alteration of the mechanisms regulating the physiological synergy among these synaptic components is defined as "synaptopathy." Mutations in the genes encoding for proteins involved in neuronal transmission are associated with several neuropsychiatric disorders ...[more]
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