Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects.

ABSTRACT: Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Exper

SUBMITTER: Schuler-Faccini L 

PROVIDER: S-EPMC8957982 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature