Ontology highlight
ABSTRACT:
SUBMITTER: Halfmann PJ
PROVIDER: S-EPMC8958134 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Halfmann Peter J PJ Kuroda Makoto M Maemura Tadashi T Chiba Shiho S Armbrust Tammy T Wright Ryan R Balaram Ariane A Florek Kelsey R KR Bateman Allen C AC Kawaoka Yoshihiro Y
Cell reports 20220328 3
The emergence of the SARS-CoV-2 Omicron (B.1.1.529) variant with a surprising number of spike mutations raises concerns about reduced sensitivity of this virus to antibody neutralization and subsequent vaccine breakthrough infections. Here, we infect Moderna mRNA-vaccinated or previously infected hamsters with the Omicron BA.1 variant. While the Moderna mRNA vaccine reduces viral loads in the respiratory tissues upon challenge with an early S-614G isolate, the vaccine efficacy is not as pronounc ...[more]