SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis.

ABSTRACT: A novel coronavirus (SARS-CoV-2) has devastated the globe as a pandemic that has killed millions of people. Widespread vaccination is still uncertain, so many scientific efforts have been directed toward discovering antiviral treatments. Many drugs are being investigated to inhibit the coronavirus main protease, 3CLpro, from cleaving its viral polyprotein, but few publications have addressed this protease's interactions with the host proteome or their probable contribution to virulence. Too few host protein cleavages have been experimentally verified to fully understand 3CLpro's global effects on relevant cellular pathways and tissues. Here, I set out to determine this protease's targets and corresponding potential drug targets. Using a neural network trained on cleavages from 392 coronavi

SUBMITTER: Prescott L 

PROVIDER: S-EPMC8958254 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature