Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration.

ABSTRACT: Unpredictable outbreaks due to respiratory viral infections emphasize the need for new drug delivery strategies to the entire respiratory tract. As viral attack is not limited to a specific anatomic region, antiviral therapy that targets both the upper and lower respiratory tract would be most effective. This study aimed to formulate tamibarotene, a retinoid derivative previously reported to display broad-spectrum antiviral activity against influenza and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), as a novel dual particle size powder formulation that targets both the nasal cavity and the lung by a single route of intranasal administration. Spray freeze drying (SFD) and spray drying (SD) techniques were employed to prepare tamibarotene powder formulations, and cyclodextrin

SUBMITTER: Seow HC 

PROVIDER: S-EPMC8958263 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature