Upconversion nanoparticles@AgBiS₂ core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers.

ABSTRACT: UCNPs@AgBiS₂ core-shell nanoparticles that AgBiS₂ coated on the surface of upconversion nanoparticles (UCNPs) was successfully prepared through an ion exchange reaction. The photothermal conversion efficiency of AgBiS₂ can be improved from 14.7% to 45% due to the cross relaxation between Nd ions and AgBiS₂. The doping concentration of Nd ions played a critical role in the production of reactive oxygen species (ROS) and enhanced the photothermal conversion efficiency. The NaYF₄:Yb/Er/Nd@NaYF₄:Nd nanoparticles endows strong upconversion emissions when the doped concentration of Nd ions is 1% in the inner core, which excites the AgBiS₂ shell to produce ROS for photodynamic therapy (PDT) of cancer cells. As a result,

SUBMITTER: Chu Z 

PROVIDER: S-EPMC8958283 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature