Sense and Sensibilities of Organ Perfusion as a Kidney and Liver Viability Assessment Platform.

ABSTRACT: Predicting organ viability before transplantation remains one of the most challenging and ambitious objectives in transplant surgery. Waitlist mortality is high while transplantable organs are discarded. Currently, around 20% of deceased donor kidneys and livers are discarded because of "poor organ quality", Decisions to discard are still mainly a subjective judgement since there are only limited reliable tools predictive of outcome available. Organ perfusion technology has been posed as a platform for pre-transplant organ viability assessment. Markers of graft injury and function as well as perfusion parameters have been investigated as possible viability markers during ex-situ hypothermic and normothermic perfusion. We provide an overview of the available evidence for the use of k

SUBMITTER: Verstraeten L 

PROVIDER: S-EPMC8958413 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature