Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery.

ABSTRACT: Stroke is the leading cause of death and disability. Currently, there is no effective pharmacological treatment for this disease, which can be partially attributed to the inability to efficiently deliver therapeutics to the brain. Here we report the development of natural compound-derived nanoparticles (NPs), which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain. First, we screened a collection of natural nanomaterials and identified betulinic acid (BA) as one of the most potent antioxidants for stroke treatment. Next, we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine (BAM) and for targeted drug delivery through surface conjugat

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8958421 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature