Magnetically responsive nanofibrous ceramic scaffolds for on-demand motion and drug delivery.

ABSTRACT: Smart biomaterials, featuring not only bioactivity, but also dynamic responsiveness to external stimuli, are desired for biomedical applications, such as regenerative medicine, and hold great potential to expand the boundaries of the modern clinical practice. Herein, a magnetically responsive three-dimensional scaffold with sandwich structure is developed by using hydroxyapatite (HA) nanowires and ferrosoferric oxide (Fe₃O₄) nanoparticles as building blocks. The magnetic HA/Fe₃O₄ scaffold is fully inorganic in nature, but shows polymeric hydrogel-like characteristics including a 3D fibrous network that is highly porous (>99.7% free volume), deformable (50% deformation) and elastic, and tunable stiffness. The magnetic HA/Fe₃O₄

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8958423 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature