Adoptive transfer of metabolically reprogrammed macrophages for atherosclerosis treatment in diabetic ApoE ^-/- mice.

ABSTRACT: Atherosclerosis is characterized by inflammation in the arterial wall, which is known to be exacerbated by diabetes. Therapeutic repression of inflammation is a promising strategy for treating atherosclerosis. In this study, we showed that diabetes aggravated atherosclerosis in apolipoproteinE knockout (ApoE ^-/-) mice, in which increased expression of long-chain acyl-CoA synthetase 1 (Acsl1) in macrophages played an important role. Knockdown of Acsl1 in macrophages (Mφ ^shAcsl1 ) reprogrammed macrophages to an anti-inflammatory phenotype, especially under hyperglycemic conditions. Injection of Mφ ^shAcsl1 reprogrammed macrophages into streptozotocin (STZ)-induced diabetic ApoE ^-/- mice (ApoE ^-/-

SUBMITTER: Wang T 

PROVIDER: S-EPMC8958426 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature