M⁶A Regulator-Mediated Methylation Modification Patterns and Characterisation of Tumour Microenvironment Infiltration in Non-Small Cell Lung Cancer.

ABSTRACT:

Purpose

The role of RNA N6-methyladenosine (m⁶A) modification in the progression of multiple tumours and the tumour microenvironment (TME) has been progressively demonstrated and promises a new direction for tumour therapy. However, there have been no reports on systematic analyses of RNA m⁶A modification in TME in non-small cell lung cancer (NSCLC).

Patients and methods

In this study, we used unsupervised cluster analysis to identify three m⁶A modification patterns of 28 m⁶A regulators and three m⁶A gene signature subgroups of commonly differentially expressed genes (co-DEGs) in the three m⁶A modification patterns. Quantifying these subtypes using the ssGSEA and ESTIMATE algorithms to characterise the tumour

SUBMITTER: Fan Y 

PROVIDER: S-EPMC8958726 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature