Modeling Interaction and Dispersion Effects in the Analysis of Gene-by-Environment Interaction.

ABSTRACT: Genotype-by-environment interaction (GxE) studies probe heterogeneity in response to risk factors or interventions. Popular methods for estimation of GxE examine multiplicative interactions between individual genetic and environmental measures. However, risk factors and interventions may modulate the total variance of an epidemiological outcome that itself represents the aggregation of many other etiological components. We expand the traditional GxE model to directly model genetic and environmental moderation of the dispersion of the outcome. We derive a test statistic, [Formula: see text], for inferring whether an interaction identified between individual genetic and environmental measures represents a more general pattern of moderation of the total variance in the phenotype by either the

SUBMITTER: Domingue BW 

PROVIDER: S-EPMC8958844 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature