Acute kidney injury-attributable mortality in critically ill patients with sepsis.

ABSTRACT:

Background

To assess whether acute kidney injury (AKI) is independently associated with hospital mortality in ICU patients with sepsis, and estimate the excess AKI-related mortality attributable to AKI.

Methods

We analyzed adult patients from two distinct retrospective critically ill cohorts: (1) Medical Information Mart for Intensive Care IV (MIMIC IV; n = 15,610) cohort and (2) Wenzhou (n = 1,341) cohort. AKI was defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We applied multivariate logistic and linear regression models to assess the hospital and ICU mortality, hospital length-of-stay (LOS), and ICU LOS. The excess attributable mortality for AKI in ICU patients with sepsis was further evaluated.

Results

AKI occurred in 5,225 sub

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8958971 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature