Association Between Hypernatremia and Delirium After Cardiac Surgery: A Nested Case-Control Study.

ABSTRACT:

Background

The association between hypernatremia and delirium after cardiac surgery has rarely been investigated. This study aimed to determine whether hypernatremia increases the risk of delirium after exposure.

Materials and methods

From April 2016 to June 2021, 7,831 consecutive patients receiving cardiac surgery were screened for potential enrollment. The primary outcome was postoperative delirium (POD). For the respective case of delirium, 10 controls were matched according to the index date within the nested case-control design. Hypernatremia exposure was defined as serum sodium > 145 mmol/L within 7 days before the index date. A generalized estimation equation was performed to assess excess risks for POD associated with hypernatremia, adjusted for demographics and cli

SUBMITTER: Hong L 

PROVIDER: S-EPMC8959150 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature