Association of Ovar-DRB1 alleles with innate immune responses in sheep.

ABSTRACT:

Background

Major histocompatibility complex (MHC) is the best characterised genetic region associated with adaptive immune responses, including humoral and cell-mediated immunities.

Objectives

In this study, the association of MHC class II alleles with inflammatory cytokines and acute-phase proteins was evaluated in sheep population.

Methods

Allelic diversity of second exon of ovine DRB1 locus (Ovar-DRB1.2) was determined in 100 indigenous Iranian Lori-Bakhtiari fat-tailed sheep using restriction fragment length polymorphism and direct sequencing methods. The association of DRB1.2 alleles with inflammatory cytokines (interleukin-1β, IL-1β; IL-6 and tumour necrosis factor-α) and acute-phase proteins (serum amyloid A, alpha-1-acid glycoprotein and haptoglobin) was exami

SUBMITTER: Esmailnejad A 

PROVIDER: S-EPMC8959254 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature