Effects of berberine on the pharmacokinetics of florfenicol and levels of cytochrome P450 3A37, multidrug resistance 1, and chicken xenobiotic-sensing orphan nuclear receptor mRNA expression in broilers.

ABSTRACT:

Background

Berberine (BBR) is always used in combination with florfenicol for treating avian in China.

Objective

This study aims to investigate the effects of BBR on the pharmacokinetics of florfenicol in broilers.

Methods

Male broilers were randomly divided into the control group and the BBR group (BG). Note that 50 mg/kg BBR or sterile water was orally administrated to broilers. On the 8th day, florfenicol [30 mg/kg body weight (BW)] was orally administered to broilers in both groups. The plasma concentrations of florfenicol were determined by ultra-high-performance liquid chromatography (UHPLC). The levels of cytochrome P450 (CYP) 3A37, multidrug resistance 1 (MDR1), and chicken xenobiotic-sensing orphan nuclear receptor (CXR) mRNA expression in the liver and jejun

SUBMITTER: Li S 

PROVIDER: S-EPMC8959326 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature