Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity.

ABSTRACT: Although obesity has been a longstanding health crisis, the genetic architecture of the disease remains poorly understood. Genome-wide association studies have identified many genomic loci associated with obesity, with genes being enriched in the brain, particularly in the hypothalamus. This points to the role of the central nervous system (CNS) in predisposition to obesity, and we emphasize here several key genes along the satiety signaling pathway involved in genetic susceptibility. Interest has also risen regarding the chronic, low-grade obesity-associated inflammation, with a growing concern toward inflammation in the hypothalamus as a precursor to obesity. Recent studies have found that genetic variation in inflammatory genes play a role in obesity susceptibility, and we highlight her

SUBMITTER: Szalanczy AM 

PROVIDER: S-EPMC8959400 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature