Elevated Serum Leptin Levels as a Predictive Marker for Polycystic Ovary Syndrome.

ABSTRACT:

Background

Leptin may have important implications in polycystic ovary syndrome (PCOS)-related metabolic disorders. However, the changes in serum leptin levels in patients with PCOS and its predictive value for PCOS remain obscure. We intend to analyze the association between leptin and PCOS in this study.

Materials and methods

The study comprised 89 patients with PCOS and 139 individuals without PCOS. Each group was stratified as either normal- or hyper-fasting serum insulin (FSI), and lean or overweight/obese; and the patients were further categorized as normal- or hyper-androgenic. The validity of leptin toward the diagnosis of PCOS, or leptin combined with total testosterone, dehydroepiandrosterone sulfate (DHEAS), and free testosterone was estimated by receiver operating

SUBMITTER: Peng Y 

PROVIDER: S-EPMC8959426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature